Non-respiring Rat Liver Mitochondria Do Not Have a Ca2+/2H+ Antiporter.

A quantitative analysis of super-stoichiometric H+ ejection and Ca 2+ uptake in respiring rat liver mitochondria.

Experiments described in this paper provide an explanation for super-stoichiometry of respiration-dependent uptake of Ca2+ and ejection of H+ by mitochondria, i.e. Ca2+/2eratios greatly exceeding 2.0 per site and correspondingly increased H+/2eratios when the medium is devoid of phosphate. In rat liver mitochondria super-stoichiometry is evoked by Ca2+ concentrations in excess of 60 to 80 ng-io...

Rat-liver Mitochondria and Microsomes

Work by Marinetti, Erbland & Stotz (1958) on pig-heart-cell fractions and by Macfarlane, Gray & Wheeldon (1960) on rat-liver-cell fractions have indicated that the mitochondrial and microsomal phospholipids may differ significantly in composition. In view of the results obtained by Collins (1960) and by Collins & Shotlander (1961), showing the widespread occurrence of complex amino-phospholipid...

Sulphite in Rat Liver Mitochondria

1. The mechanism of sulphite and sulphate permeation into rat liver mitochondria was investigated. 2. Extramitochondrial sulphite and sulphate elicit efflux of intramitochondrial phosphate, malate, succinate and malonate. The sulphate-dependent effluxes and the sulphite-dependent efflux of dicarboxylate anions are inhibited by butylmalonate, phenylsuccinate and mersalyl. Inhibition of the phosp...

Do Liver Transplant Recipients Have a Higher Risk for Cryptococcosis Than Non-liver Transplant Recipients?

Dietary Omega-3 Fatty Acids Do Not Change Resistance of Rat Brain or Liver Mitochondria to Ca2+ and/or Prooxidants

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) block apoptotic neuronal cell death and are strongly neuroprotective in acute and chronic neurodegeneration. Theoretical considerations, indirect data, and consideration of parsimony lead to the hypothesis that modulation of mitochondrial pathway(s) underlies at least some of the neuroprotective effects of n-3 PUFAs. We therefore systematically te...